The design of the present research was a quasi-experimental method. The purpose of this study was to examine the effect of sand therapy and finger color box on reduction of anxiety and increasing of positive feeling as well as general adjustment level of children suffering blood cancer. Sample of the study was composed of 30 in-patients by using accidental sampling in age group of 9-12 that admitted in the children medical center (Tehran). In this study subject's anxiety, positive feeling as well as general adjustment level was tested using the Rotter's Incomplete Sentences Test, Berger Children Anxiety Scale, both before and after therapy. The experimental group of research was under 12 sessions of therapy and training was based on weekly session for four weeks. In this study the researcher performed a pretest-post test design and repeated measures procedure. After finishing the therapy, the obtained data were analyzed by descriptive statistics and t test for dependent groups. The results showed that sand therapy and finger color box had effective role in increasing of positive feeling, general adjustment level and reduction of anxiety.